Package: diffHTS
Type: Package
Title: Differential Drug Sensitivity Analysis for Two-Condition
        High-Throughput Screens
Version: 0.1.0
Authors@R: 
    person("Liang", "Tang", email = "xphdtangliang@gmail.com", role = c("aut", "cre"))
Description: A complete workflow for large-scale, two-condition
    high-throughput drug screening (HTS). It compares drug sensitivity between
    any two experimental conditions - for example irradiated versus
    non-irradiated cells, cancer versus normal cell lines, or treated versus
    untreated samples - across many plates and experiments. The package covers
    the full pipeline: control-based normalisation, plate-level quality-control
    metrics (Z-factor, Z-prime, signal-to-background, signal-to-noise and
    strictly standardised mean difference), replicate-consistency checks,
    four-parameter logistic dose-response fitting with area under the curve
    (AUC) estimation, differential (delta) AUC scoring with within-plate
    standardisation, cut-off and sigma-based hit selection, and
    publication-ready heatmap, scatter and quality-control visualisations.
License: GPL-3
Encoding: UTF-8
LazyData: true
Depends: R (>= 4.1)
Imports: tidyr, rlang, ggplot2, graphics, stats, utils
Suggests: ComplexHeatmap, circlize, ggprism, ggrepel, grid, readxl,
        testthat (>= 3.0.0), knitr, rmarkdown
VignetteBuilder: knitr
Config/testthat/edition: 3
Config/roxygen2/version: 8.0.0
NeedsCompilation: no
Packaged: 2026-07-18 17:37:57 UTC; wd979071
Author: Liang Tang [aut, cre]
Maintainer: Liang Tang <xphdtangliang@gmail.com>
Repository: CRAN
Date/Publication: 2026-07-28 16:10:08 UTC
Built: R 4.5.2; ; 2026-07-28 18:42:34 UTC; unix
