Package: wnl
Version: 0.8.6
Title: Minimization Tool for Pharmacokinetic-Pharmacodynamic Data
        Analysis
Description: This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model. 
Depends: R (>= 3.5.0)
Imports: numDeriv
Authors@R: person(given="Kyun-Seop", family="Bae", role=c("aut", "cre", "cph"), email="k@acr.kr")
Author: Kyun-Seop Bae [aut, cre, cph]
Maintainer: Kyun-Seop Bae <k@acr.kr>
Copyright: 2017-, Kyun-Seop Bae
License: GPL-3
NeedsCompilation: no
LazyLoad: yes
Repository: CRAN
URL: https://cran.r-project.org/package=wnl
Contact: k@acr.kr
Packaged: 2026-07-26 07:18:20 UTC; Kyun-SeopBae
Date/Publication: 2026-07-26 07:50:02 UTC
Built: R 4.5.2; ; 2026-07-26 11:27:40 UTC; unix
