Package: SATS
Title: Signature Analyzer for Targeted Sequencing
Version: 1.0.10
Date: 2026-07-02
Authors@R: c(person(given="DongHyuk", family="Lee", role="aut", email="dhyuklee@pusan.ac.kr"),
             person(given="Bin", family="Zhu", role="aut", email="bin.zhu@nih.gov"),
             person(given="Bill", family="Wheeler", role="cre", email="wheelerb@imsweb.com"))
Description: SATS stands for Signature Analyzer for Targeted Sequencing and performs mutational signature analysis for targeted sequenced tumors. Unlike the canonical analysis of mutational signatures, SATS factorizes the mutation counts matrix into a panel context matrix (measuring the size of the targeted sequenced genome for each tumor in the unit of million base pairs (Mb)), a signature profile matrix, and a signature activity matrix. SATS also calculates the expected number of mutations attributed by a signature, namely signature burden, for each targeted sequenced tumor. For more details see Lee et al. (2024) <doi:10.1101/2023.05.18.23290188>.
Imports: stats, glmnet, GenomicRanges, IRanges, Biostrings, dplyr,
Depends: R (>= 4.1.0)
Suggests: testthat, BSgenome.Hsapiens.UCSC.hg19,
        BSgenome.Hsapiens.UCSC.hg38
License: GPL-2
NeedsCompilation: yes
Packaged: 2026-07-02 14:55:01 UTC; wheelerwi
Author: DongHyuk Lee [aut],
  Bin Zhu [aut],
  Bill Wheeler [cre]
Maintainer: Bill Wheeler <wheelerb@imsweb.com>
Repository: CRAN
Date/Publication: 2026-07-09 09:40:07 UTC
Built: R 4.6.1; x86_64-w64-mingw32; 2026-08-23 03:15:38 UTC; windows
Archs: x64
