# Scenario Guide

Use this guide to pick a module and test for your study design.

## Implemented scenarios (48 tests)

Module | Tests
--- | ---
biomarker | 7
clinical | 11
workspace | 30

### Power Workspace (30 tests)

Classical families: t, F, chi-square, exact proportions, z correlations/GLM, Wilcoxon rank tests.

### Biomarker Discovery (7 tests)

ROC/AUC, diagnostic accuracy, log-rank, Cox, FDR screening, differential expression.

### Clinical Trials (11 tests)

Superiority, NI, equivalence (TOST), Simon two-stage, cluster RCT, multi-arm ANOVA, Poisson counts, survival.

## Decision table

Study question | Module | Example test
--- | --- | ---
Two-group mean difference | Power Workspace or Clinical | `t_two_sample`, `rct_superiority_continuous`
Paired / pre-post | Power Workspace | `t_paired`
One-way ANOVA | Power Workspace or Clinical | `f_anova_one_way`, `multi_arm_superiority`
Multiple regression \(R^2\) | Power Workspace | `f_mreg_omnibus`
Two proportions (Fisher) | Power Workspace or Clinical | `exact_fisher`, `rct_superiority_binary`
McNemar paired proportions | Power Workspace | `exact_mcnemar`
Correlation difference | Power Workspace | `z_corr_independent`
Logistic / Poisson GLM | Power Workspace or Clinical | `z_logistic`, `count_endpoint_poisson`
Biomarker AUC | Biomarker | `roc_auc_one`
Diagnostic sens/spec | Biomarker | `diagnostic_acc`
Survival / HR | Biomarker or Clinical | `cox_regression`, `survival_pmu`
Non-inferiority trial | Clinical | `rct_noninferiority_continuous`
Bioequivalence (TOST) | Clinical | `rct_equivalence_continuous`
Oncology Phase II Simon | Clinical | `simon_two_stage`
Cluster RCT | Clinical | `cluster_rct`
Omics screening + FDR | Biomarker | `discovery_fdr`

## Not yet implemented

Document for planning only — use external tools or custom simulation:

- Group sequential / interim analyses
- Crossover or repeated-measures RCT
- Dunnett pairwise multi-arm comparisons
- Paired / correlated ROC comparison
- Partial AUC, NPV/PPV as primary endpoints
- Time-varying accrual and dropout in survival
- Bayesian assurance
- Simon optimal design search (minimax / optimal)

## Related

- Choosing a power analysis
- Support matrix
- Formula reference (pkgdown only)