A scalable and accurate tool for Killer-cell Immunoglobulin-like Receptor (KIR) genotype imputation directly from SNP array data using supervised machine learning models trained across five continental ancestry groups. Uses attribute bagging and an ensemble classifier method with haplotype inference for SNPs and KIR types. Models are built from global populations in the 1000 Genomes Project and validated across diverse biobank cohorts. Methods are based on Zheng et al. (2014) <doi:10.1016/j.ajhg.2013.12.015> and Sadeeq et al. (2026) <https://github.com/NormanLabUCD/PONG2>.
| Version: | 1.0.1 |
| Depends: | R (≥ 4.0.0) |
| Imports: | parallel, graphics, stats, utils, tools |
| LinkingTo: | Rcpp, RcppParallel |
| Suggests: | HIBAG, knitr, rmarkdown, pkgdown, testthat |
| Published: | 2026-06-24 |
| DOI: | 10.32614/CRAN.package.PONG2 (may not be active yet) |
| Author: | Suraju A. Sadeeq [aut, cre], Laura A. Leaton [aut], Katherine M. Kichula [aut], Paul J. Norman [aut], Xiuwen Zheng [ctb, cph] (Original HIBAG C++ code adapted in src/PONG.cpp and src/LibKIR.cpp) |
| Maintainer: | Suraju A. Sadeeq <suraju.sadeeq at cuanschutz.edu> |
| BugReports: | https://github.com/NormanLabUCD/PONG2/issues |
| License: | GPL-3 |
| URL: | https://normanlabucd.github.io/PONG2/, https://github.com/NormanLabUCD/PONG2 |
| NeedsCompilation: | yes |
| SystemRequirements: | PLINK2 (>= 2.0), minimac4 (>= 4.1.6, optional) |
| Materials: | README |
| CRAN checks: | PONG2 results |
| Package source: | PONG2_1.0.1.tar.gz |
| Windows binaries: | r-devel: not available, r-release: not available, r-oldrel: not available |
| macOS binaries: | r-release (arm64): PONG2_1.0.1.tgz, r-oldrel (arm64): PONG2_1.0.1.tgz, r-release (x86_64): PONG2_1.0.1.tgz, r-oldrel (x86_64): PONG2_1.0.1.tgz |
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